Endosporin is used: in animal husbandry and poultry farming and in fish farming.

Endosporin is a highly effective probiotic that is also effective as a feed additive, which includes 2 strains of bacteria Bacillus amyloliquefaciens. The drug in the form of a solution or in a dry lyophilized state is a cellular biomass of two active spore-forming cultures, which complement and enhance the effect of each other. Registered in Ukraine.

The drug has a wide spectrum of action:

  • antimicrobial action, suppresses pathogenic and opportunistic microflora and does not affect representatives of normal microflora;
  • improves feed digestibility;
  • has an immunomodulatory effect;
  • contributes to increasing the mass of animals and preserving livestock;
  • does not cause the formation of resistant forms of strains of pathogenic bacteria.

Mechanism of action:

1) antibacterial, antifungal, antimicrobial the effect of strains-components of the drug is based on their ability to synthesize antibiotics - surfactin, fengycin, bacillibactin, bacillaen, macrolactin, difficidin, which suppress the development and reproduction of a wide range of pathogenic microorganisms. In addition, synthesized Bacillus subtilis bacteriolytic and yeast-lytic enzymes destroy the cell walls of pathogenic bacteria, which enhances the antagonistic effect of the drug;
2) increasing feed conversion occurs due to the synthesis by strains of enzymes (cellulases, proteases, lipases, amylases), which break down proteins, fats, carbohydrates, fiber and thereby contribute to improving digestion and assimilation of feed;
3) immunomodulatory effect occurs by increasing the synthesis of endogenous interferon and activating the phagocytic activity of leukocytes and macrophages;
4) increasing the mass of livestock is due to the synthesis by strains of numerous biologically active substances - vitamins, amino acids, etc., which have a positive effect on metabolism;
5) spore probiotic is more stable to the adverse effects of the aggressive environment of the gastrointestinal tract, retains its vital activity for a longer time, exhibits high antagonistic activity against a wide range of pathogenic microflora and can be used as an alternative to antibiotics.


  • treatment and prevention of dysbiosis;
  • treatment and prevention of intestinal and purulent infections;
  • treatment and prevention of postpartum endometritis, fetal membrane retention (poop);
  • other inflammatory diseases of the birth canal.

Norms of use of Endosporin


Application procedure

Broilers aged from 0 to 7 days;

Broilers from the 18th day;

Productive birds;

5-10 ml per 100 heads for 5-7 days;

Laying hens

5-10 ml per 100 heads for 6 days, 2 times a month;



300-400 ml per 100 heads 15 days before farrowing and throughout the lactation period

Newborn piglets

100-200 ml per 100 heads for 12-14 days

Piglets for fattening weighing up to 10-15 kg

100 ml per 100 heads for 7 days

Piglets for fattening weighing from 10-15 kg to 30-40 kg

3-4 liters per 1t of water


Piglets weighing 50-60 kg before slaughter

2-3 liters per 1 ton of water

Fish farming 

Preparation of breeders for spawning

0.5 l per 1 ton of waterи in 7-10 daysів before spawnу

Maintenance and rearing of larvae

1 liter per 1 ton of waterи 1 once a month

Breeding of fish of older age groups

0.2 l per 1 ton of waterи 1 once a month.

Compatibility with chemicals

Endosporin can be used as an alternative to antibiotics.

The effectiveness of the drug

  • preservation of the bird population by 2.3%;
  • increase in egg production by 3.5%;
  • an increase in the live weight of chickens when drinking from the first day by 6%;
  • reduction of pathogenic microflora: staphylococci by almost 100%, proteus by 22.7%, candida by 35.5%, when chickens are watered from the 1st day;
  • the economic effect of use in veterinary practice is 15%.

Available documentation: Patent of Ukraine. Technical conditions, Instructions for use.

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