Лабораторія інновацій та трансферу технологій - ІМВ НАН України 🇺🇦

Head of Department: Larysa Safronova 

doctor of biol. science.,

senior researcher

Ph.: 294-69-74

E-mail: safronova_larisa@ukr.net

Scientific areas of laboratory

  1. Identifying and ensuring the acquisition of rights of protection documents for objects of intellectual property (IPR) and support of registered IPR.
  2. Transfer and commercialization of scientific developments.
  3. Licensing activity, including international.
  4. Protection of the Institute's IPR rights.
  5. Study of the biological activity of bacterial preparations.
  6. Development and approval in relevant institutions of scientific and technical documentation for microbial biological preparations.
  7. Overview of the market of biological preparations in the field of interests of the Institute.
  8. Advertising, popularization of scientific developments of the Institute.

Main achievements

  1. More than 30 license agreements for 20 objects of intellectual property for the production of biological preparations in the field of medicine, veterinary medicine and agriculture, developed by the Institute, including international ones from the USA, Slovakia, and the Czech Republic, have been concluded and are in effect.
  2. Successful protection of the Institute's IPR rights in courts of various levels (for example, the invention is protected by Ukrainian patent No. 73682 dated August 15, 2005). The patentability of the said invention was subject to review by national courts. According to the results of the case review, the corresponding patent No. 73682 was upheld, as evidenced by the decision of the Supreme Court dated February 20, 2020, the decision of the Northern Commercial Court of Appeal dated October 2, 2019, and the decision of the Kyiv Commercial Court dated March 1, 2019 in case No. 910/ 13287/17.
  3. Organization of the Institute's participation in international agro-industrial commercial exhibitions on a regular basis in order to popularize and advertise scientific developments.
  4. Organization of the conference with the participation of scientific staff of the Institute and licensees "The role of biological preparations in ensuring the environmental friendliness of products and reducing their cost price" within the framework of the International Agro-Industrial Exhibition "INTERAGRO 2016".
  5. Presentation of the Institute's developments and the main directions of research in the agro-industrial sector - International agro-industrial exhibition "AgroSpring 2020".

According to the results of the competition for 2017, the Institute took the 1st place for achieving better performance in inventive work, creation, protection and use of intellectual property objects at the Department of Biochemistry, Physiology, and Molecular Biology of the National Academy of Sciences of Ukraine. For 2015 and 2021 - the 2nd place.     

in accordance with the resolution of the Presidium of the National Academy of Sciences of Ukraine dated May 16, 2018 No. 159

Keywords: licenses, technology transfer, intellectual property objects, patents, trademarks, microbial preparations

History

The Laboratory of Innovation and Technology Transfer was founded in 2008 in accordance with the Law of Ukraine "On State Regulation of Activities in the Field of Technology Transfer", Resolution of the Cabinet of Ministers of Ukraine dated August 1, 2007 No. 995 "Some Issues of Implementation of the Law of Ukraine "On State Regulation of Activities in the Field of technology transfer" and Resolution of the Presidium of the National Academy of Sciences of Ukraine No. 15 of January 16, 2007 with the aim of increasing the level of protection of intellectual property rights in the institutions of the National Academy of Sciences of Ukraine, as well as ensuring the implementation and commercialization of the results of the Institute's scientific activities.

Scientific work

New results of a comprehensive study of probiotic properties of bacterial strains of the genus were obtained Bacillus as components of an effective drug, the regularities of the interaction of spore probiotics with the macroorganism have been established. It is shown that the potential of bacterial cultures for the creation of probiotics is determined not by their species, but by their unique strain characteristics.

A new complex enzyme preparation with a wide range of proteolytic activities: fibrinolytic, elastase, collagenase, caseinolytic, was isolated from the culture liquid of probiotic strains of bacilli - the basis of the veterinary drug Endosporin. The antioxidant properties of these strains were studied. It was established that bacterial cultures synthesize a number of acids of the phenolic and benzoic structure (gallic, 4-hydroxyphenylacetic, caffeic, syringic, p-coumaric, trans-ferulic and trans-cinnamic acids), which have powerful antioxidant properties and are able to protect animal hepatocytes from toxic effects CCl4.

Clinical studies have been conducted and the scope of use of probiotic drugs - biosporin in dental practice in children's CRS has been expanded; subalin in the complex treatment of children with chronic viral hepatitis, intestinal dysbacteriosis, endotoxicosis syndrome. The expediency of prescribing subalin for complex immunorehabilitation treatment of patients with chronic obstructive pulmonary disease is shown.

It has been established that the treatment of agricultural products with the drug Fitosubtil based on bacteria of the genus Bacillus provides effective protection of grapes, sugar beet roots and potatoes against phytopathogenic bacterial and fungal microflora during long-term storage. Also, the use of the drug for the pre-sowing treatment of soybean seeds ensures a reduction in the level of damage to plants by bacteria and viruses during the growing season in conditions of natural and artificial infection. In addition, the drug promotes the stimulation of plant growth, which has a positive effect on the yield of grain mass from the plant, grain yield and its quality (protein and fat content).

Conferences
  • International scientific conference "Microbiology and immunology - development prospects in the 21st century" (April 10-11, 2014, Kyiv, Ukraine).
  • II International scientific conference “Microbiology and immunology – the development outlook in the 21st century” (April 14-15, 2016, Kyiv, Ukraine).
  • XV Congress of the Society of Microbiologists of Ukraine named after S.M. Vinogradsky (September 11-15, 2017, Odesa, Ukraine).
  • 2017 CBEP Ukraine Regional One Health Research Symposium and Peer Review Session (24-28 April, 2017, Kyiv, Ukraine)
  • Presentation of the Institute’s developments in the laboratory of Ecology Institute of Shandong Academy of Sciences (Sep. 19, 2019, China,)
  • New opportunities for Ukrainian scientists to participate in interdisciplinary competitions of the EU program "Horizon-2020" (November 21, 2014)
  • Information session "Horizon-2020" "Actions of Marie Skladovska-Curie" and "Future technologies" (10.12.2014)
Seminars and training
  • World Intellectual Property Organization - WIPO Academy "On the basics of patent documentation preparation" (2021)
  • Technology and innovation support centers in Ukraine SE Ukrpatent - Lecture-webinar, organized "Forming and submission of international applications under the PCT procedure to the receiving Office. (2021)
  • Technology and Innovation Support Centers in Ukraine SE Ukrpatent - Webinar "Features of conducting a qualification examination of an invention application" (2021)
  • IP Center of Ukraine - Development of relations in the field of intellectual property - mediation in the field of intellectual property. Gained knowledge on effective pre-trial settlement of disputes. (2020)
  • World Intellectual Property Organization – Academy«General course on intellectual property» (2020)
  • The World Intellectual Property Organization - the Madrid Monitor service and the global brand database Madrid Monitor and the Global Brand Database. Acquiring practical skills in searching for claimed, registered trademarks that may appear confusing in WIPO's searchable databases to avoid refusals in TM applications. (2020)
  • Startup Mastery Basic Level interactive workshop. (2019)
  • Practical seminar Organizer: SE "Premier Expo" - on increasing the efficiency of participation in exhibitions (2017)
  • 2 seminars-conferences in the field AT Marketing organized by AIIBIZ companies andB2B Academy, held in April 2016.
  • The seminar "Transfer of technologies and objects of intellectual property in universities", which was held on October 20, 2016 at UkrINTEI
Participation in exhibitions

The laboratory annually presents and advertises the Institute's scientific developments at exhibitions of various thematic orientations.

  • All-Ukrainian Science Festival
  • Exhibition-presentation of scientific achievements of the institutions of the National Academy of Sciences of Ukraine together with the KMDA "Made in Kyiv" within the framework of the Science Festival
  • International specialized exhibition of pharmaceutical products "Pharmaexpo"
  • International health care exhibition "MEDICAEXPO"
  • International exhibition "HI-TECH EXPO. High technologies"
  • International Forum "Innovation market" and International Eastern European Forum "Innovative Economy and Science"
  • International exhibition "FRUITS. VEGETABLES. LOGISTICS", "GRAIN TECHNOLOGIES", "AGRO ANIMAL SHOW", "AgroVesna"
  • International exhibition "InterAgro"
  • International agro-industrial exhibition "AGRO-2016, 2018, 2019"
  • AgroComplex international exhibition
  • International exhibition LABCompLEX. Analytics. Laboratory. HI-TECH biotechnology"
  • The exhibition is devoted to Ukrainian inventions in the field of medicine at the time of Ukraine's independence
  • Festival of innovative projects "Sikorsky Challenge 2017"
  • Festivals of innovation projects "Sikorsky Challenge" on the basis of innovation holding Sikorsky Challenge of the Science Park "Kyiv Polytechnic" with the support of grant and venture funds. (2019)
Publications
  1. Сафронова Л.А. Биологическая активность пробиотических  штаммов бацилл – основы препарата эндоспорина. Доповіді НАН України. – 2015.- №6.-С.138-146.
  2. E.V.Маtseliukh, L.A. Safronova, L. D. Varbanets.  Bacillus amyloliquefaciens subsp. Plantarum Probiotic strains as protease producers. Biotechnologia acta. – 2015. –  V.8, № 2.  – P.84- 90.
  3. Сафронова Л.А. Влияние аминокислот на литическую  активность штаммов  Bacillus amyloliquefaciens subsp. plantarum. Мікробіологія і біотехнологія – 2015.- № 1(29). – С.50-59.
  4. Сафронова Л.А., Діденко Г.В. Вплив пробіотика ендоспорину на показники системи імунітету у інтактних тварин. Наукові доповіді НУБіП України – 2015. – №51(березень).
  5. Сафронова Л.А., Діденко Г.В. Імуномодулюючі та протипухлинні властивості  спорового пробіотику Наукові доповіді НУБіП України – 2015.- №52(квітень).
  6. Зубочов С.Р., Сафронова Л.А.  Біологічний метод – основа органічного землеробства. Посібник українського хлібороба.– 2016.–Т.1– С.259-264.
  7. Kiprianova E.A., Safronova L. A., Prosyanov A. O. Antimicrobial, entomopathogenic and antiviral activity of gaupsin biopreparation created on the basis of Pseudomonas chlororaphis strains. Biotechnologia acta. –  2017. –  V. 10, N 1. – С.7-16.
  8. Сафронова Л.А., Иляш В.П.  Биосинтетическая активность бацилл,            обусловливающая их пробиотический эффект. Мікробіол. журн. –  2017. –  Т. 79, №6. – С.120-136.
  9. Сафронова Л.А., Коваленко Н.К. Національна академія наук України Видатні досягнення 1918-2018.  «Пробіотична активність мікроорганізмів: фундаментальні аспекти створення функціональних продуктів і препаратів та впровадження їх в медичну та ветеринарну практику», Київ. Фенікс, 2018. – С.188-189.
  10. Сафронова Л.А., Иляш В.П. Современное состояние проблемы пробиотических  препаратов.  Мікробіол. журн. –  2019. –  Т. 81, №5. – С.114-140.
  11. Сафронова Л.А., Скороход І.О. Композиція пробіотичних штамів Bacillusamyloliquefaciens ssp. plantarum, що мають антиоксидантну активність. Патент України №140654. Бюл.№ 5, 10.03.2020 р.
  12. Oleg N. Reva, Safronova A. Larisa, Aneth D. Mwakilili, Donatha Tibuhwa, Sylvester Lyantagaye, Wai Yin Chan,Stefanie Lutz,  Christian H. Ahrens,  Joachim Vater, Rainer Borriss. Complete genome sequence and epigenetic profile of Bacillus velezensis UCMB5140 used for plant and crop protection in comparison with other plant-associated Bacillus strains // Applied Microbiology and Biotechnology (2020) 104:7643–7656
  13. Safronova L.A., Voychuk S.I., Brovarska O.S. Influence of nanobiocomposites on the exopolysaccharide matrixof Bacillus strains // Dopov. Nac. akad. nauk Ukr. –  2020.– №8.-C.81-91.
  14. Кипріанова О.А., Сафронова Л.А. Біологічний замінник фунгіцидів та інсектицидів / Зерно.– 2020. –№1(166).­– С. 156-161
  15. Safronova, L.S., Skorochod, I.A., Ilyash, V.M. Antioxidant and Antiradical Properties of Probiotic Strains Bacillus amyloliquefaciens ssp. Plantarum // Probiotics Antimicro. Prot. (2021). https://doi.org/10.1007/s12602-021-09827-y
  16. Сафронова Л.А., Скороход І.О.  Потенціал бактерій роду Bacillus як пробіотиків / Здоров’я України,№ 13-14 (506-507), Липень 2021 р.
Publications in the field of intellectual property
  1. Сафронова Л.  Щодо відсутності  належного   захисту прав на штами мікроорганізмів як об’єктів інтелектуальної власності / Інтелектуальна власність в Україні.–  2020.– №3. –С.11-17.
  2. Василенко О.Г., Сафронова Л.А. Проблеми процесу комерціалізації результатів наукової діяльності на стадіях з інноваційним лагом. Інтелектуальна власність в Україні. –2019. –  №10. – С. 39-47.
  3. Сафронова Л.А., Василенко О.Г., «Проблеми введення інтелектуальної власності в господарський оборот України».- ХІ Міжнародна науково-практична конференція«ІНФОРМАЦІЯ, АНАЛІЗ, ПРОГНОЗ – СТРАТЕГІЧНІ ВАЖЕЛІ ЕФЕКТИВНОГО ДЕРЖАВНОГО УПРАВЛІННЯ» – 2018р.
  4. Сафронова Л.А., Василенко О.Г., «Про актуальні питання комерціалізації трансферу технологій». УкрІНТЕІ у рамках V Міжнародного форуму 2017 “Проблеми інноваційного розвитку та інформаційного суспільства.» – 2017р.
Patents

1.         Patent of Ukraine for the invention No. 76669 dated August 15, 2006. Biological preparation for the treatment and prevention of intestinal and purulent infections in animals / Safronova L.A., Osadcha A.I., Kudryavtsev V.O.

2. Patent of Ukraine for a utility model No. 77141 dated January 25, 2013. Biopreparation "Fitosubtil" for processing root crops and potatoes during their storage / Safronova L.A., Nudga A.Yu., Avdeeva L.V.

3. Patent of Ukraine for a utility model No. 126995 dated July 10, 2018. Complex biological preparation for antifungal and antibacterial treatment of plants based on bacteria of the genus  Pseudomonas / Kiprianova O. A., Safronova L. A., Avdeeva L. V., Skrotskyi S. O.

4. Ukrainian utility model patent No. 140654 dated March 10, 2020. Composition of probiotic strains Bacillus amyloliquefaciens ssp. plantarum, which have antioxidant activity / Safronova L.A., Skorokhod I.O.

Cooperation

Registration of intellectual property objects, participation in webinars, trainings, events organized SE Ukrpatent

EnterpriseEuropenetwork – International platform for science and business (presentation of the Institute's developments)

Scientific Research Institute of Intellectual Property Legal Academy of Sciences of Ukraine

Network of Technology and Innovation Support Centers (TISCs) - an international project of the World Intellectual Property Organization, which has been implemented in Ukraine since 2018 on the basis of the Memorandum of Understanding between the Ministry of Economic Development and Trade of Ukraine and the World Intellectual Property Organization (WIPO) regarding the creation of Technology and Innovation Support Centers in Ukraine dated July 26, 2018. The TISC project from WIPO has been implemented since 2009 in more than 80 countries of the world.

Trials of the biological preparation Fitosubtil and participation in the Specialized Academic Council for the Defense of Dissertations

National Development & Innovations Foundation NDI Foundation (National Development and Innovation Foundation) is a non-profit organization established in 2015. The Foundation conducts events for the presentation of the development business of Institutes of the National Academy of Sciences of Ukraine

Ecology Institute of Shandong Academy of Sciences (China) - cooperation on microbial preparations for crop production

Biotechnological Center of Applied and Molecular Microbiology (Spain) - cooperation on preparations for crop production

Publication of the Institute's developments
Employees of the department

Larysa Safronova 

Head of the laboratory

Doctor of biological sciences, senior researcher

Ph.: 294-69-74

E-mail: safronova_larisa@ukr.net

Olena Vasylenko

Deputy head of the laboratory, leading engineer,

specialist in the field of intellectual property,

master of intellectual property management

Remote learning in World Intellectual Property Organization (WIPO):

  • WIPO Academy «General course on intellectual property»
  • WIPO Academy "On the basics of patent documentation preparation"

Oksana Nasikovska

Leading engineer

Primary accounting of intellectual property objects

Remote learning in World Intellectual Property Organization (WIPO): WIPO Academy "Basics of Intellectual Property"

Nataliia Naumenko

Leading engineer

Formation of application materials for IP rights, maintaining the validity of registered patents

Awards

Safronova L.A. was awarded the Certificate of Honor of the Presidium of the National Academy of Sciences of Ukraine, the Central Committee of the Trade Union of Employees of the National Academy of Sciences of Ukraine for many years of fruitful work, significant creative achievements in the field of microbiology and virology, solving the fundamental problems of creating and introducing the latest biotechnological preparations and products (Resolution of the Presidium of the National Academy of Sciences of Ukraine dated 27.06. 2018).
The best invention - 2008 in the field of agro-industrial complex
. Patent of Ukraine for the invention No. 76669. Biopreparation for the treatment and prevention of intestinal and purulent infections in animals / Safronova L.A., Osadcha A.I., Kudryavtsev V.O.