Polymer matrices on the basis of polyacrylamide and β‐cyclodextrin‐containing pseudorotaxane for prolonged drug release: Synthesis and properties

Abstract Polymer cross‐linked matrices based on polyacrylamide (PAA) and β‐cyclodextrin‐pseudorotaxane have been designed. The structure and properties of the objects synthesized were confirmed and studied by a series of methods, involving ultraviolet‐, Fourier transform infrared‐spectroscopy, thermal mass spectrometry, DSC, X‐ray diffraction analysis (WAXS and SAXS). Desorption kinetics (especially significant slowing of desorption process) of some drugs, like metoprolol succinate and loratadine from obtained polymer matrices is shown to be optimal with 10 wt% β‐CD‐pseudorotaxane in their structure.

DOI: https://doi.org/10.1002/app.50554